Endocrine Abstracts

As one of the oldest targets for molecular imaging and targeted radionuclide therapy, characterization of the sodium iodide symporter (NIS) as a novel reporter and suicide gene offers the possibility of NIS gene transfer in nonthyroidal tumors followed by diagnostic and therapeutic application of radioiodine. Our previous work has convincingly demonstrated the high efficacy of radionuclide therapy after tumor-selective NIS gene delivery. As logical consequence of our pioneer s...

The sodium iodide symporter (NIS) is an intrinsic plasma membrane glycoprotein that mediates the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in particular lactating mammary gland. In addition to its key function in thyroid physiology, NIS-mediated iodide accumulation allows diagnostic thyroid scintigraphy as well as therapeutic radioiodine application in benign and malignant thyroid disease. Functional NIS expression in differentiate...

Wound healing and tumour stroma formation are associated with angiogenesis and require interactions of various different cell types. We and others have shown that mesenchymal stem cells (MSCs) differentiate into fibroblast-/pericyte-like cells and secrete proangiogenic factors. Thyroid hormones act as proangiogenic modulators mediated by non-genomic mechanisms via cell surface receptor integrin αvβ3. The aim of this study is to evaluate the stimulatory activity of T3...

Tumour stroma formation is associated with angiogenesis and requires interactions of various different cell types, including endothelial cells and mesenchymal stem cells (MSCs), which are actively recruited into growing tumour stroma. Thyroid hormones T3 and T4 act as non-classical proangiogenic modulators mediated by non-genomic mechanisms via cell surface receptor integrin αvβ3. The deaminated T4 derivative tetrac is a specific inhibitor of thyroid hormone action a...

The well characterized sodium iodide symporter (NIS) in its dual function as reporter and therapy gene displays an outstanding opportunity to target different cancer types allowing non-invasive imaging of functional NIS expression and therapeutic radionuclide application. We recently reported induction of tumor-selective accumulation and therapeutic efficacy of radioiodide after systemic non-viral epidermal growth factor receptor (EGFR)-targeted NIS gene delivery in a subcutan...

The tumor-homing property of mesenchymal stem cells (MSC) has led to their use as delivery vehicles for therapeutic genes such as the sodium iodide symporter (NIS), which has convincingly been demonstrated by our recent studies of systemic NIS gene delivery using MSCs as delivery vehicles in both subcutaneous and orthotopic xenograft mouse models. External beam radiation therapy (EBRT) represents a promising tool in the application of engineered MSC (eMSCs)-based gene therapy ...

Due to limited treatment options the prognosis of patients with advanced hepatocellular cancer (HCC) has remained poor. We therefore examined the feasibility of radioiodine therapy of HCC after human sodium iodide symporter (hNIS) gene transfer, using the tumor-specific alpha-fetoprotein (AFP) promoter for transcriptional targeting. For this purpose NIS gene transfer was performed in vivo in human HCC cell (HepG2) xenografts, using replication-deficient adenoviral vecto...

Context: Anaplastic (ATC) thyroid carcinoma is an orphan disease accounting for about 2% of all malignant thyroid tumors. ATC confers a dismal prognosis and standard treatment is not established.Objective: To describe the epidemiology, current treatment regimens and outcome of ATC, to identify clinical prognostic markers and treatment factors associated with improved prognosis. To establish a consensus treatment schedule.Design: Re...

The sodium iodide symporter (NIS) in its role as well characterized reporter and therapy gene represents an outstanding tool to target different cancer types allowing non-invasive imaging of functional NIS expression by 123I-scintigraphy and therapeutic application of 131I. Based on its overexpression on the surface of the vast majority of cancer types, the cMET/Hepatocyte growth factor receptor (HGFR) serves as an ideal target for tumor-selective gene de...

We have recently demonstrated induction of tumor-selective accumulation and therapeutic efficacy of radioiodine in neuroblastoma tumors after systemic non-viral polyplex-mediated sodium-iodide-symporter (NIS) gene delivery.In the current study, we evaluated the efficacy of novel synthetic nanoparticle vectors based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG), and coupled with the synthetic peptide GE11 as an epidermal growth ...